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Item EH021003: If offspring carry an allele that is not present in the body cells of its parents, then the allele resulted from a mutation in the sex cells of one of the parents. (Identify sound reasoning.) (MC1R gene in mice)

Observation: Two grey mice had a baby mouse pup that was black.

Question: How did grey parents produce a black mouse pup?

Claim: A new allele of the MC1R gene was produced by mutation in one of the parent’s sex cells, and then passed on to the mouse pup.

Evidence: DNA sequencing revealed that the mouse pup has an allele of the MC1R gene that results in the production of more black pigment in the fur. Neither parent has a copy of this black MC1R allele in its body cells.

Which of the following statements provides the best reasoning to justify why the evidence supports the claim?

  1. Mutation is a natural process that produces genetic variation.
  2. DNA is passed from parents to offspring so that each individual has half their genetic information from their father and half their genetic information from their mother.
  3. Since offspring inherit DNA from their parents, if neither parent carried the black MC1R allele in its body cells, the allele must have been produced by mutation in a parent’s sex cell.
  4. Mutation happens when errors are made in copying the DNA, sometimes as a result of environmental causes.

Pre-Test

Distribution of responses (prior to studying evolution in high school)
Answer Choice
Overall
Grades
Gender
Primary Language
 
n = 572
6–8
n = 18
9–12
n = 502
Male
n = 245
Female
n = 283
English
n = 511
Other
n = 18
A. Mutation is a natural process that produces genetic variation. 16% 22% 16% 19% 13% 16% 6%
B. DNA is passed from parents to offspring so that each individual has half their genetic information from their father and half their genetic information from their mother. 27% 22% 27% 28% 27% 27% 28%
C. Since offspring inherit DNA from their parents, if neither parent carried the black MC1R allele in its body cells, the allele must have been produced by mutation in a parent’s sex cell. 48% 44% 48% 45% 51% 48% 50%
D. Mutation happens when errors are made in copying the DNA, sometimes as a result of environmental causes. 9% 11% 9% 9% 9% 9% 17%

Post-Test (Control)

Distribution of responses (following typical high school instruction on evolution)
Answer Choice
Overall
Grades
Gender
Primary Language
 
n = 274
6–8
n = 14
9–12
n = 230
Male
n = 119
Female
n = 130
English
n = 237
Other
n = 9
A. Mutation is a natural process that produces genetic variation. 22% 36% 23% 26% 19% 24% 0%
B. DNA is passed from parents to offspring so that each individual has half their genetic information from their father and half their genetic information from their mother. 19% 14% 19% 23% 15% 18% 33%
C. Since offspring inherit DNA from their parents, if neither parent carried the black MC1R allele in its body cells, the allele must have been produced by mutation in a parent’s sex cell. 47% 43% 47% 39% 56% 47% 44%
D. Mutation happens when errors are made in copying the DNA, sometimes as a result of environmental causes. 12% 7% 11% 12% 10% 11% 22%

Post-Test (Treatment)

Distribution of responses (following completion of an evolution curriculum module)
Answer Choice
Overall
Grades
Gender
Primary Language
 
n = 278
6–8
n = 4
9–12
n = 248
Male
n = 130
Female
n = 131
English
n = 251
Other
n = 5
A. Mutation is a natural process that produces genetic variation. 19% 25% 20% 22% 16% 20% 20%
B. DNA is passed from parents to offspring so that each individual has half their genetic information from their father and half their genetic information from their mother. 10% 25% 10% 12% 7% 10% 20%
C. Since offspring inherit DNA from their parents, if neither parent carried the black MC1R allele in its body cells, the allele must have been produced by mutation in a parent’s sex cell. 57% 50% 56% 50% 63% 57% 60%
D. Mutation happens when errors are made in copying the DNA, sometimes as a result of environmental causes. 14% 0% 14% 15% 14% 14% 0%